Can CBD Help You Sleep Better and Support Your Immune System? Here’s What the Science Says

You wake up tired, even after eight hours in bed. The stress from the day lingers long into the night. And just when you start to feel like you’re getting back on track, a cold knocks you off your feet again. Sound familiar?

In a world where good sleep and a resilient immune system are more important - and more elusive - than ever, many people are turning to natural ways to support their wellbeing. And one name keeps coming up: CBD.

Touted as a gentle, plant-based supplement for everything from calm to recovery, cannabidiol (CBD) - a cannabinoid that can be found in the hemp and cannabis plant - is showing up in CBD oils, CBD gummies, CBD vapes and CBD capsules around the world. But beyond the hype, what does the actual science say? A recent clinical study may have some answers, and they’re more than just promising.

cbd oil

What the Study Looked At (and Why It’s Unique)

A team of researchers in the US set out to explore a simple but surprisingly understudied question: What happens when healthy people take CBD every day?

Most studies on CBD have focused on people with medical conditions - epilepsy, anxiety disorders, sleep disorders, chronic pain. But this one looked at 28 healthy adults, aged around 26, who didn’t already use cannabis or CBD. Participants were randomly given either 50 mg of CBD or a placebo every day for eight weeks. The CBD came in capsule form and was taken about an hour before bed.

The researchers then tracked the effects of CBD in terms of how well the study participants slept, how they felt, and how their immune cells were functioning - specifically a type called natural killer (NK) cells, which play a key role in early immune responses.

This wasn’t about curing illness or managing symptoms. It was about understanding whether a modest daily amount of CBD could enhance everyday wellbeing.

Key Finding #1: Better Sleep, Naturally

Let’s start with sleep. The researchers used a detailed sleep questionnaire called the Leeds Sleep Evaluation Questionnaire (LSEQ), which assesses how easily someone falls asleep, how rested they feel in the morning, and the overall quality of their sleep experience.

After eight weeks, those who had taken the capsules that contain CBD reported a significant improvement in multiple areas:

  • Falling asleep felt easier

  • The sleep itself felt more restorative

  • Waking up felt more refreshing

In short, their sleep felt better - even if it wasn’t significantly longer or deeper in measurable terms.

Interestingly, when sleep was tracked using wrist actigraphy (a wearable tracker similar to a Fitbit), the amount of sleep and time spent in bed didn’t change much. This suggests that the subjective experience of sleep - the way it feels, rather than just the numbers - may be where CBD makes a noticeable difference.

And that’s no small thing. Feeling better-rested can impact everything from focus to energy levels to mood throughout the day.

Key Finding #2: A Quiet Boost to Immune Function

One of the more surprising findings from the study was CBD’s effect on the immune system - specifically on NK cells, which act like the body’s internal security team, identifying and destroying unhealthy cells.

After eight weeks of supplementation, participants in the CBD group showed improved NK cell activity in laboratory tests. That means their immune cells were better at targeting and neutralising threats when exposed to them in a controlled setting.

This doesn’t mean CBD will prevent illness or act like a vaccine! But it does suggest that CBD may gently support the body’s natural immune defences - something many people look for, especially during stressful or high-risk times of year.

It’s also worth noting that this boost came without stimulating the immune system in a potentially harmful way. Instead, it seemed to help immune cells work more effectively when they were needed.

CBD Products were Well Tolerated

When adding any new supplement to your daily routine, safety and tolerability are key concerns. This study found that the 50 mg CBD per day dose was well tolerated by all participants.

There were no negative changes in:

  • Body weight or composition

  • Mood, anxiety, or depression levels

  • Fatigue or mental alertness

In other words, participants didn’t experience side effects like grogginess, low energy, or mood swings - common worries when people hear the word “cannabinoid”.

This finding aligns with a growing body of evidence suggesting that CBD is safe for most people when taken in moderate doses. And while more long-term research is needed, it provides useful reassurance for those considering a dose of CBD as part of their wellness routine.

CBD Oil for Everyday Health

While the study didn’t claim CBD could treat or cure anything, it did offer strong indications that it might support two foundational areas of wellbeing: sleep and immune function.

These are areas that many people struggle with, even if they’re otherwise healthy. Poor sleep doesn’t just affect your energy levels; it can also make you more susceptible to illness, increase stress, and reduce your capacity to recover physically and mentally.

Likewise, a sluggish immune system may not make headlines in your daily life - but when it’s running below its best, you’re more likely to catch what’s going around, feel rundown, or have slower post-workout recovery.

So, if a simple, plant-based supplement can help support both without side effects, it’s no wonder CBD oil for sleep has become a go-to for many.

Should You Use CBD Products for Sleep or Immune Health?

That depends on your body, your goals, and how you respond to supplements. But if you’re someone who:

  • Often wakes up feeling unrefreshed

  • Struggles to fall asleep without relying on melatonin or harsh sleep aids

  • Wants to support your immune system during busy or stressful times

  • Is looking for a natural, non-intoxicating way to enhance your daily routine

…then CBD could be worth exploring.

Of course, it’s important to choose high-quality products. The best CBD brands use third-party testing, clearly label their ingredients, and avoid unnecessary additives. CBD Oils, CBD patches, and CBD gummies are popular formats, and you may need to experiment to find what works best for you.

And as always, if you’re taking medication or managing a health condition, check with your healthcare provider first!

cbd oil

CBD for Sleep: A Small Step with Big Potential

There’s no shortage of bold claims in the wellness world. But this study offers something more grounded: evidence that CBD, taken daily at a common dose of 50 mg, may help people sleep better and support their natural immune response - without side effects or disruption to daily life.

It’s not a miracle cure. But for those looking to feel more rested, resilient, and balanced, taking CBD for sleep might just be a helpful addition. Because sometimes, the best changes are the gentle ones - the ones that help you feel like yourself, only better.

Curious to learn more? Reach out with any questions - our team is here to help!

Sources

[1] Kisiolek JN, Flores VA, Ramani A, Butler B, Haughian JM, Stewart LK. Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity. Nutrients. 2023;15(4173).

 

Portrait of Anna Falk

written by

anna falk - head of product

As the Head of Product at Harmony, Dr Anna Falk leads the development of our products and provides expert tips for your wellness. With over 10 years of experience in the research and development of natural products, her work is based on rigorous scientific studies.

Anna is an award-winning, internationally published researcher with a PhD in Organic Chemistry. She applies her expertise to develop Harmony's certified products that support your overall well-being. From research to development, she ensures that our products are of the highest quality and meet the highest standards.